This paper analyzes and practices the intelligent monitoring and early warning in the sensitive area, designs the intelligent monitoring and early warning system suitable for the sensitive area by using multithreading, database, target detection and tracking, blockchain and other technologies, and realizes the positioning, detection, tracking, shooting, warehousing, early warning, query, management of suspicious dynamic and static objects, solves the “crash” and other problems in monitoring programming. In order to ensure the high security of monitoring and early warning data, this paper discusses the storage of relevant data by blockchain technology, determines the deletion of data by the consensus algorithm, describes the key technology and implementation process, and carries out experimental verification and analysis of video fluency. This paper takes the safety construction of “double first class” university laboratory as an example to verify the system.