Abstract: With the rapid development of Cloud Platform, Mobile Office and BYOD Office have swept across the world. Companies take Cloud Desktop Office as the preferred, and build Cloud Desktop environment. However, the new office environment will also introduce the new security issues. Currently, Cloud Desktop security architecture has not yet formed. Knowledge of Cloud Desktop defense is relatively scarce. Domestic also lack of comprehensive, system, effective defense model. Cloud desktop virtualization structure determines its defense structure is no longer a string type, to a certain extent; cloud server defense is more sensitive than traditional one. This paper proposed an active defense scheme of offensive and defensive feedback defense graph on which applicable to cloud desktop by analysis cloud desktop defense architecture. It unfolded the restructuring process of its defense and attack, marked the targeted attacks design according to the defense analysis, and feedback attack graph to security defense, and then optimized the defense map. It adopted reverse breadth search algorithm to find attack vulnerable points, no reliable attack path was missed or repeated. It introduces the offensive and defensive game model, to compliance with the principle of appropriate security. Finally, this paper revealed simulation process of offensive and defensive feedback defense graph on cloud desktop through a famous provider of cloud desktop.